Specialized Tools for Electrophysiology and Cell Biology Research

(DP-301) Differential Amplifier

Product Summary

The DP-301 is a single channel AC/DC differential preamplifier highly suited for EEG, EKG and extracellular recording.


  • High input impedance
  • High common mode rejection
  • Low noise with high gain
  • High tolerance to DC offsets
  • Bandwidth filtering available

High Input Z, High CMR

High common mode rejection is very important in minimizing electrical interference. The high input resistance of the DP-301 (1012 ohm typical) ensures that the instrument's high CMR will not be degraded by differences in source impedance at the input. This is important in extracellular recording, where the difference in resistance of the recording and indifferent electrode is often large.

High DC Tolerance

Extracellular action potentials are typically measured in microvolts but are usually accompanied by much larger DC electrode voltages. The DP-301 is designed to amplify these microvolt level events with as much as ± 3 VDC at the input.

High Gain, Low Noise and Bandwidth Limiting

Gain selections of x100, x1000 and x10000. Microvolt signals are sufficiently amplified for computer data acquisition and recorder inputs. Noise is very low, typically 10 µV p-p at 1 Hz to 10 kHz bandwidth. Reducing the bandwidth with the low pass and high pass filters further lowers noise.

Calibration Signal

The internal Cal signal provides a convenient check of amplifier gain and operation.

Battery Powered/Portable

The single channel DP-301 is powered with 4 standard 9 V transistor batteries yielding approximately 500 hours of normal operation. The small size of the DP-301 makes it possible to be placed at the measurement site or inside a Faraday cage. End of battery life is indicated by the Low Bat light.

Input Cables

The standard IC-2S input cables (2 per channel) which are not terminated at the outboard end.
Optionally available are cables with 2 mm pin and alligator clip (p/n IC-4M).
IC-4M Cable shown to right

Summary of Features

  • Single channel AC/DC pre-amplifier designed for amplifying weak signals such as EEG, EKG and extracellular action potentials.
  • Battery powered amplifier with very low noise of 10 microvolts peak-to-peak (1-Hz to 10-kHz with input shorted)
  • High gain with selections of x100, x1000 and x10,000. Thus microvolt (µV) level signals sufficiently amplified for computer data acquisition and signal analysis.
  • Excellent common mode rejection of 100 dB min (100,000:1) at 60 Hz with input resistance 1012 ohm typical.
  • Both high pass and low pass filters, each with 4 switch settings.
  • DC offset of ± 600 millivolt at output BNC operates in both AC or DC modes.
  • A front panel calibrate push button applies 1mV pulse to the amplifier input to check intermediate gains and support equipment.

The amplifier is fully compatible with the HEKA data acquisition system.

Voltage Gain, AC/DC x100, x1,000 and x10,000
Input Resistance 1012 Ω typical
Leakage Current 50 pA typical
Common Mode Rejection 100 dB min (100,000:1) at 60 Hz
Noise, input shorted 10 µV p-p,
1 Hz to 10 kHz
Low Frequency Filter Settings (high pass) 0.1, 1.0, 10 and 300 Hz
High Frequency Filter Settings (low pass) 0.1, 1.0, 3.0 and 10 kHz
Calibration Signal 1 mV p-p at 10 Hz
Max. Common Mode Signal ± 3 V
Output Voltage Swing ± 10 V
Output Resistance 220 Ω
Input and Output Connectors BNC
Power Requirements 4 x 9 V alkaline batteries
Physical Size 8.8 x 20 x 17.5 cm
(H x W x D)
Shipping Weight 2.3 kg
Warranty Two years, parts and labor
(excluding batteries)
Order No. Model No. Product Description USA Price Order
64-0047 IC-4M Replacement input cable set with 2 mm pin and alligator clip on outboard end, BNC on inboard end, 2 pack Login Login


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Order No. Model No. Product Description USA Price Order
64-0044IC DP-301 Differential Amplifier with IC-4M Cables Login Login
64-0044 DP-301 Differential Amplifier with IC-2S Cables Login Login
Data Acquisition
64-2325 IX-408 8 Channel data recorder with Labscribe software Login Login
64-2431 IX-416 16 channel data recorder with Labscribe software Login Login
460-7032 BNC-2 BNC to BNC cable, 2 feet (Pomona) Login Login
460-7013 BNC-6 BNC to BNC cable, 6 feet (Pomona) Login Login
Replacement Parts
64-0047 IC-4M Replacement input cable set with 2 mm pin and alligator clip on outboard end, BNC on inboard end, 2 pack Login Login
64-0046 IC-2S Replacement standard input cable set, 2 pack Login Login
460-8090 2U Rack handle Login Login

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