Specialized Tools for Electrophysiology and Cell Biology Research

(SHM-6, SHM-8) Multi-Line In-Line Solution Heaters

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Product Summary

Multi-line in-line solution heating is the simplest and most effective method of warming multiple perfusion solutions to the same temperature.

  • SHM-6 six-line and SHM-8 eight-line solution heaters
  • Compatible with our TC-344C (dual) and TC-324C (single) channel temperature controllers
  • Temperature of 37°C can be maintained at ± 0.2°C

In-line solution heating is the simplest and most effective method of warming perfusion solutions. The minimal dead space manifold at the output of the in-line solution heater allows it to be used in any application where from 2 to 8 perfusion lines are required to be connected to a chamber or other device.

The output from the heater is connected to the chamber using a short length of tubing such that the warmed perfusate flows directly into the chamber bath. Connections are made by press fitting PE-160 tubing onto the 18 gauge stainless steel hypodermic tubes. Cap plugs are supplied to block any unused inputs.

Depending on bath volume and other factors, inline solution heating itself may be sufficient for many applications. (Solution reservoir heaters from Warner Instruments are recommended if outgassing of solutions is a problem.) The SHM Series heaters will accommodate flow rates up to 5 mL/min while maintaining 37°C.

Each heater is supplied with a TA-29 thermistor cable assembly (shown on the right) which allows for monitoring the actual bath temperature (T2 output on the heater controller), and 3 meters of PE-160 tubing. Both are compatible with Warner's TC-344C  and  TC-324C temperature controllers.

Heater Resistance 10Ω
Voltage Requirement Variable 0 to 12 VDC max.
Maximum Temperature 65°C
Internal Dead Volume 94 µL
Manifold Dead Volume 30 µL (manifold input to output)
Maximum Flow Rate at 37°C
SHM-6 5 mL/min
SHM-8 5 mL/min
Physical Dimensions
Body 16.5 mm x 165 (D x L)
Cable 1.9 m
Weight 104 g
Warranty 1 year
Temperature of 37°C can be maintained at ± 0.2°C under following conditions:
Condition A Solution temperature at input (nominally 21°C) varies no more than ±10%
Condition B Solution flow rate varies no more than 25% with 5 mL min/max flow rate
Order No. Model No. Product Description USA Price Order
64-0107 TA-29 Cable with bead thermistor Login Login
64-0108 TA-30 Cable with glass thermistor Login Login
64-0755 PE-160/10 Polyethylene tubing, PE-160, 10 ft Login Login
64-2401 TC-344C Heater controller, dual channel, 110-230 VAC, 50/60Hz Login Login
64-2400 TC-324C Heater controller, single channel, 110-230 VAC, 50/60Hz Login Login

References

References

  1. Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice
    Ni D, Lee LY
    Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L897-904
  2. Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model
    Yao X, Anderson DL, Ross SA, Lang DG, Desai BZ, Cooper DC, Wheelan P, McIntyre MS, Bergquist ML, MacKenzie KI, Becherer JD, Hashim MA
    Br J Pharmacol. 2008 Aug;154(7):1446-56
  3. Dynamics of Somatostatin Type 2A Receptor Cargoes in Living Hippocampal Neurons
    Lelouvier B, Tamagno G, Kaindl AM, Roland A, Lelievre V, Le Verche V, Loudes C, Gressens P, Faivre-Baumann A, Lenkei Z, Dournaud P
    J Neurosci. 2008 Apr 23;28(17):4336-49
  4. Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons
    Ni D, Lee LY
    Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L563-71
  5. Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
    Kopp C, Longordo F, Nicholson JR, Lüthi A
    J Neurosci. 2006 Nov 29;26(48):12456-65
  6. Glial Cell Line-Derived Neurotrophic Factor Family Members Sensitize Nociceptors In Vitro and Produce Thermal Hyperalgesia In Vivo
    Sacha A. Malin, Derek C. Molliver, H. Richard Koerber, Pamela Cornuet, Rebecca Frye, Kathryn M. Albers, and Brian M. Davis
    The Journal of Neuroscience, August 16, 2006, 26(33):8588-8599
  7. Compensatory Responses to Pyruvate Carboxylase Suppression in Islet -Cells
    Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB
    J Biol Chem. 2006 Aug 4;281(31):22342-51
  8. MOLECULAR MECHANISMS OF AGING IN THE PERIPHERAL NOCICEPTIVE SYSTEM
    Shuying Wang
    Submitted to the Graduate Faculty of School of Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2006
  9. Artemin Regulates Nociceptor Responses to Thermal and Chemical Stimuli
    Christopher Michael Elitt
    Dissertation univ of Pittsburgh, 2006
  10. TRPV3 is a calcium-permeable temperature-sensitive cation channel
    Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE
    Nature. 2002 Jul 11;418(6894):181-6

Customers from Europe and Australia can use the Multi Channel Systems - Online Shop to order Warner products or create quotes.

Order No. Model No. Product Description USA Price Order
64-0104 SHM-6 Line In-Line Solution Heaters (SHM-6, SHM-Six-line solution heater Login Login
64-0105 SHM-8 Line In-Line Solution Heaters (SHM-6, SHM-Eight-line solution heater Login Login
Accessories and Replacement Parts
64-0060 MB-B Magnetic base; main pole (12 x 176 mm, D x L), Sub Pole (10 x 165 mm, D x L), 800 N hold force, MM-33 compatible Login Login
64-0107 TA-29 Cable with bead thermistor Login Login
64-0755 PE-160/10 Polyethylene tubing, PE-160, 10 ft Login Login
64-0108 TA-30 Cable with glass thermistor Login Login
64-2400 TC-324C Heater controller, single channel, 110-230 VAC, 50/60Hz Login Login
64-2401 TC-344C Heater controller, dual channel, 110-230 VAC, 50/60Hz Login Login
64-0564 U9404 Utility Clamp Login Login

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