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Specialized Tools for Electrophysiology and Cell Biology Research

(CL-100) Single Channel Bipolar Temperature Controller

Product Summary

The CL-100 Temperature Controller is a single channel controller capable of accurately maintaining a Peltier device between 0° and +50°C, or a resistive heating element between ambient and +65°C.


  • Quiet operation suitable for electrophysiology applications
  • Can be used with both Peltier devices (e.g.SC-20) and resistive heating applications (e.g. Series 20 platforms)
  • Built-in protection for Peltier devices
  • Single control temperature adjustment
  • Freeze alert and alarm circuitry
  • External inputs for computer control of set temperature or applied voltage

The CL-100 Temperature Controller is a single channel controller capable of accurately maintaining a Peltier device between 0° and 50°C. Power for the instrument is provided by an ultra low noise power supply making it suitable for use in sensitive electrophysiology applications. The CL-100 will also maintain a resistive heating element from ambient to +65°C (requires the use of an ACC-1 adapter cable).

While the instrument has several uses, it was specifically designed to control the SC-20 Dual In-line Solution Heater/Cooler. (Shown to the right.) When coupled with the SC-20, the CL-100 provides efficient control of perfusion solution temperatures. Both of these instruments in-turn provide heating and cooling to our PHC Series heater/cooler jackets and for some of Warner'sSeries 20 Open Bath Recording Chambers.

All Warner Peltier-driven devices require the use of the LCS-1 Liquid Cooling System to maintain temperature control.


The CL-100 is simple to use with a single control for temperature adjustment. It sports two BNC inputs for external computer control of either the set temperature or the applied voltage level. It can simultaneously monitor the system temperature (i.e. the temperature of the feedback thermistor situated within SC-20) and a separate, secondary point of interest in the experimental set-up (e.g. a chamber bath thermistor). Two BNC output connectors are provided to send these thermistor readings to a data acquisition system or chart recorder.


The CL-100 provides automatic control using a feedback loop as well as a manual mode. A loop-speed selector (i.e. fast, medium, or slow) is used to optimize the feedback response of the system to accommodate the intrinsic thermal delay characteristics of the setup. Built-in circuitry limits the maximum temperature of the Peltier to prevent damage and a freeze alert/alarm indicates when the cold side of the Peltier reaches 0°C.

The heater/cooler jacket can be used to bring heating and cooling to the Series 20 recording and imaging chambers.

Maximum Output Voltage ± 15 V DC
Maximum Output Current 2.4 Amps
Maximum Output Power 36 W (8 Ω load)
Manual Voltage Range 0 to ± 15 V
Temperature Range

0 to 50°C via Peltier-device
Ambient to +65°C via resistive heating

Recorder Outputs

Control Temp Out 100 mV/°C
Monitor Temp Out 100 mV/°C


Front Panel BNC for external thermistor
Rear Panel BNC for external set temp
Rear Panel BNC for external voltage set
Rear Panel 15 pin Female 'D' Input/Output

3 1/2 digit LED display
Set Temperature, 0-50°C maximum
Control Temperature
Monitor Temperature
Output Voltage, ± 15 V maximum
Power Requirements 100-130 or 220-240 VAC
50Hz or 60 Hz
80 VA
user selectable
Shipping Weight 5.6 kg
Warranty Two years, parts & labor
Enclosure Dimensions H x W x D
8.9 cm x 20 cm x 25.4 cm

Back View


Order No. Model No. Product Description USA Price Order.
64-1427 ACC-1 Adapter cable to connect CL-100/CL-200A to 8 pin DIN heaters Login Login



  1. Thermosensitive TRP channel pore turret is part of the temperature activation pathway
    Fan Yanga, Yuanyuan Cuia,b, KeWei Wangb, and Jie Zhenga
    March 9, 2010
  2. Inorganic Polyphosphate Modulates TRPM8 Channels
    Zakharian E, Thyagarajan B, French RJ, Pavlov E, Rohacs T
    PLoS One. 2009;4(4):e5404. Epub 2009 Apr 30
  3. Lipid Raft Segregation Modulates TRPM8 Channel Activity
    Morenilla-Palao C, Pertusa M, Meseguer V, Cabedo H, Viana F
    J Biol Chem. 2009 Apr 3;284(14):9215-24. Epub 2009 Jan 27
  4. Real-Time Passive Volume Responses of Astrocytes to Acute Osmotic and Ischemic Stress in Cortical Slices and in vivo Revealed by Two-Photon Microscopy
    Risher WC, Andrew RD, Kirov SA
    Glia. 2009 Jan 15;57(2):207-21
  5. Temperature-dependent Activation of Neurons by Continuous Near-infrared Laser
    Liang S, Yang F, Zhou C, Wang Y, Li S, Sun CK, Puglisi JL, Bers D, Sun C, Zheng J
    Cell Biochem Biophys. 2009;53(1):33-42. Epub 2008 Nov 26
  6. Pore region of TRPV3 ion channel is specifically required for heat activation
    Grandl J, Hu H, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A
    Nat Neurosci. 2008 Sep;11(9):1007-13
  7. An internal thermal sensor controlling temperature preference in Drosophila
    Hamada FN, Rosenzweig M, Kang K, Pulver SR, Ghezzi A, Jegla TJ, Garrity PA
    Nature. 2008 Jul 10;454(7201):217-20. Epub 2008 Jun 11
  8. Circadian- and Light-Dependent Regulation of Resting Membrane Potential and Spontaneous Action Potential Firing of Drosophila Circadian Pacemaker Neurons
    Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC
    J Neurophysiol. 2008 Feb;99(2):976-88. Epub 2007 Dec 12
  9. The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active
    Xiao R, Tian J, Tang J, Zhu MX
    Cell Calcium. 2008 Apr;43(4):334-43. Epub 2007 Aug 15
  10. Intracellular Zinc Elevation Measured with a “Calcium-Specific” Indicator during Ischemia and Reperfusion in Rat Hippocampus: A Question on Calcium Overload,
    Christian J. Stork and Yang V. Li,
    The Journal of Neuroscience, October 11, 2006 • 26(41):10430 –10437
  11. Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal
    Huang H, Ghosh P, van den Pol AN
    J Neurophysiol. 2006 Mar;95(3):1656-68
  12. 2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels
    Gu Q, Lin RL, Hu HZ, Zhu MX, Lee LY
    Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L932-41. Epub 2005 Jan 14
  13. Transcortical Cooling Inhibits Hippocampal-kindled Seizures in the Rat,
    Justin M. Burton, Gregory A. Peebles, Devin K. Binder, Steven M. Rothman, and Matthew D. Smyth,
    Epilepsia, 46(12):1881–1887, 2005
  14. 2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
    Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX
    J Biol Chem. 2004 Aug 20;279(34):35741-8. Epub 2004 Jun 11
  15. Calcium transients in cerebellar granule cell presynaptic terminals
    Regehr WG, Atluri PP
    Biophys J. 1995 May;68(5):2156-70
  16. Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes
    Laird DW, Revel JP
    J Cell Sci. 1990 Sep;97 ( Pt 1):109-17

Customers from Europe and Australia can use the Multi Channel Systems - Online Shop to order Warner products or create quotes.

Order No. Model No. Product Description USA Price Order
64-0352 CL-100 Bipolar temperature controller Login Login
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64-1427 ACC-1 Adapter cable to connect CL-100/CL-200A to 8 pin DIN heaters Login Login

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